2024 ASCP 40 Under Forty Honoree

 

Congratulations to
David Papke, MD, PhD, FASCP

 

David Papke, MD, PhD, FASCP


David Papke, MD, PhD, FASCP, is an assistant professor in Pathology at Harvard Medical School and an associate pathologist at Brigham and Women's Hospital (BWH) in Boston, and his research interests are primarily in the diagnosis and classification of rare neoplasms, and in mismatch repair (MMR) deficiency in human neoplasia. He received his bachelor’s degree in Nuclear Engineering at the University of Illinois, Urbana-Champaign, where he continued his education in the MD/PhD program. In his PhD work, Dr. Papke studied structure-function relationships of ion channels using experimental and computational approaches. He matriculated into the Anatomic Pathology Residency Training Program at BWH, where he also completed fellowship training in Gastrointestinal and Soft Tissue Pathology. Dr. Papke has published several papers describing rare and previously unrecognized tumor types, including plexiform myofibroblastoma, calcifying nested stromal-epithelial tumor, pseudoendocrine sarcoma, nested glomoid neoplasm, infantile sinonasal myxoma, and myxoid inflammatory myofibroblastic sarcoma. He has also published studies of laboratory tests to enable prospective diagnosis of rare neoplasms, including PDGFRA, GLI1, and cytochrome P450 1A1 immunohistochemistry, and these tests have been incorporated into clinical practice at BWH. Lastly, Dr. Papke has studied MMR deficiency in human neoplasia, including developing an algorithm to determine MMR stability status based on sequencing data (now incorporated into the sequencing pipeline at BWH), and analyzing mismatch repair status in a large cohort of colorectal adenocarcinomas, work that was published in the New England Journal of Medicine. Dr. Papke is a member of ASCP, USCAP, and the Alpha Omega Alpha Honor Society.